Optical coherence tomography
IAP RAS researchers made a significant contribution to the development of optical coherence tomography (OCT) for imaging the internal structure of biological tissues that are strongly scattering and relatively weakly absorbing media. The research team headed by V. M. Gelikonov and A. M. Sergeev created optical fiber tomographs for noninvasive (endoscopic inclusive) diagnosis of biotissue at a depth up to 2 mm with spatial resolution up to 10 µm. Optical tomograms of the cross-section of surface layers of internal organs in norm and pathology, including cancer, were obtained for the first time. An algorithm was developed for reconstructing parameters of biotissue scattering by OCT images and quantitative description of their state. The information obtained is not provided by other methods of medical diagnosis, including computer tomography and ultrasonography.
Recent developments enabled increasing the speed and informativity of OCT. Based on known fiber optics and spectral methods an endoscopic modality of OCT device for clinical applications was proposed that operates at a rate of 20 frames per second. A number of endoscopic miniature interchangeable probes were developed that may be used with all standard endoscopic equipment.
The use of the principles of broadband multiwave digital holography permitted creating a modification of an OCT device without external scanning systems, which opens up new opportunities for updating the method.